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2024 Vol.51, Issue 1 Preview Page

Animal

Anti-obesity effects of two herbal extracts in C57BL/6N mice fed high-fat diet
Hyuck Kim1†
,
Jihwan Lee2†
,
Seyeon Chang1
,
Dongcheol Song1
,
Jaewoo An1
,
Sehyun Park1
,
Kyeongho Jeon1
,
Jungseok Choi1*
,
Jinho Cho1*
1Department of Animal Science, Chungbuk National University, Cheongju 28644, Korea
2Department of Poultry Science, University of Georgia, Athens, GA 30602, USA
*Corresponding Author
†These authors equally contributed to this study as first author.
1 March 2024. pp. 87-95
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Abstract

The objective of this study was to investigate the anti-obesity effects of adding Momordica charantia (MC) and Chrysanthemum zawadskii var. latilobum (CZ) extracts to drinking water on obesity-induced mice. A total of 84 eight-week-old C57BL/6N male mice with an initial body weight (BW) of 28.11 ± 1.39 g were used in this study. All treatments were fed a highfat diet for d 28. Mice were randomly divided into seven drinking treatments (six replicate each treatment) based on the initial BW. Treatments are as follows: control (CON), normal tap water, MC 1, CON with 1% MC aqueous extract, MC 2, CON with 2% MC aqueous extract, CZ 1, CON with 1% CZ aqueous extract, CZ 2, CON with CZ aqueous extract (2%), MCZ 1, CON with 1% MC aqueous extract and 1% CZ aqueous extract, MCZ 2, CON with 2% MC aqueous extract and 2% CZ aqueous extract. During the entire period, the CZ 1, MCZ 1, and MCZ 2 significantly decreased (p < 0.05) gain to feed than CON. The CON significantly higher (p < 0.05) water intake than other treatments on d 0 to 14. The MCZ 1 significantly decreased (p < 0.05) relative (ratio of absolute organ weight to BW) organ weights, including retroperitoneal white adipose tissue (RWAT) weight and inguinal white adipose tissue (IWAT) weight, compared to CON. In conclusion, our study suggests that there was no significant difference in the antiobesity effects between MC and CZ, and MCZ 1 has synergistic effects by regulating adipose tissue.

Keywords
Anti-obesity
C57BL/6N mice
Chrysanthemum zawadskii var. latilobum
Momordica charantia
Water intake
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Information
  • Publisher :Institute of Agricultural Science, Chungnam National University
  • Publisher(Ko) :충남대학교 농업과학연구소
  • Journal Title :Korean Journal of Agricultural Science
  • Journal Title(Ko) :농업과학연구
  • Volume : 51
  • No :1
  • Pages :87-95
  • Received Date : 2023-12-04
  • Revised Date : 2024-01-22
  • Accepted Date : 2024-02-21
  • DOI :https://doi.org/10.7744/kjoas.510108
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