Korean Journal of Agricultural Science (Korean J. Agric. Sci.; KJOAS)
Indexed in KCI (Korea Citation Index), Open Access, Peer Reviewed.
pISSN 2466-2402
eISSN 2466-2410

Free radical scavenging activity of Cirsium japonicum var. maackii flower



Pang QQ, Lee S, Kim JH, Cho EJ, Free radical scavenging activity of Cirsium japonicum var. maackii flower. Korean Journal of Agricultural Science 50:19-26.

Korean Journal of Agricultural Science (Korean J. Agric. Sci.) 2023 March, Volume 50, Issue 1, pages 19-26. https://doi.org/10.7744/kjoas.20220095

Received on 03 August 2022, Revised on 08 August 2022, Accepted on 29 November 2022, Published on 30 March 2023.

Free radical scavenging activity of Cirsium japonicum var. maackii flower

Qi Qi Pang1, Sanghyun Lee2,3, Ji-Hyun Kim1,*, Eun Ju Cho1,*

1Department of Food Science and Nutrition, Pusan National University, Busan 46241, Korea

2Department of Plant Science and Technology, Chung-Ang University, Anseong 17546, Korea

3Natural Product Institute of Science and Technology, Anseong 17546, Korea

*Corresponding authors: llissunll@gmail.com, ejcho@pusan.ac.kr


Balance between reactive oxygen species (ROS) production and ROS quenching is important in all living organisms. If the balance is broken, the ROS consecutively generate other reactive species with toxic impact and cause oxidative stress, which is associated with chronic degenerative diseases including cancer and metabolic, cardiovascular, and neurodegenerative diseases. Therefore, natural materials as ROS scavengers are required and necessary to stabilize the ROS balance in the body. The aim of this study was to demonstrate and compare the antioxidant properties in ethanol extract and four different fractions (n-butanol, ethyl acetate, chloroform, n-hexane) of Cirsium japonicum var. maackii flower under in vitro assay. Cirsium japonicum var. aackii was extracted with ethanol and then partitioned with n-butanol, ethyl acetate, chloroform, and n-hexane. The antioxidant capacities of the ethanol extract and four fractions were investigated based on the ability to quench several free radicals including 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, superoxide anion radicals, and nitric oxide. All of the ethanol extract and fractions from Cirsium japonicum var. maackii flower exerted high antioxidant activities. These results suggest that the ethyl acetate fractions of ethanol extract from Cirsium japonicum var. maackii flower could provide antioxidant potential as free radical scavengers.


Cirsium japonicum var. maackii flower, oxidative stress, reactive oxygen species


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Authors Information

Qi Qi Pang, http://orcid.org/0000-0001-6831-7061

Sanghyun Lee, http://orcid.org/0000-0002-0395-207X

Ji-Hyun Kim, http://orcid.org/0000-0001-8232-2932

Eun Ju Cho, http://orcid.org/0000-0003-4282-3219

Conflicts of interest
No potential conflict of interest relevant to this article was reported.

이논문은 2021년도정부 (교육부)의재원으로한국연구재단의지원을받아수행된기초연구사업임 (No. 2021R1I1A1A01058704).